Cardiovascular Property of Resistance Training With an Emphasis on PI3K/AKT1 Genes Expression in Type 2 Diabetic Rats

Background: The potential role of exercise in physiological cardiac hypertrophy is rooted both hormonal and genetic components. Objectives: aim this study was to determine the impact resistance on expression PI3K AKT1 tissue type 2 diabetes (T2D) rats their hypertrophy. Methods: First, 21 male Wistar (220±20 g) were obese with 6-week high-fat diet (HFD) randomly assigned into non-diabetes, control T2D, groups. After inducing obesity, T2D induced by intraperitoneal injection streptozotocin (25 mg/kg) for Rats group completed a program, 5 sessions per week. PI3K/AKT1 weight ratio left ventricular heart, heart body, body compared analysis variance (ANOVA) between Results: In response induction diabetes, decreased significantly that non-diabetic (P=0.001 P=0.001, respectively). Further, training led significant increase (P=0.028) (P=0.032) (P=0.001), (P=0.001) diabetic rats. Conclusion: Resistance associated rats, improvement may be attributed signaling pathway.